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Medicinal Chemistry Section Staff
photo of Dr. Baumann
Michael H. Baumann, Ph.D.

Staff scientist | mbaumann@irp.nida.nih.gov

Michael H. Baumann received his Ph.D. in Physiology and Neurobiology from Rutgers University in 1991. His dissertation research examined the involvement of endogenous opioid peptides in regulating pituitary hormone secretion. Mike joined the NIDA IRP in 1991 as a Staff Fellow in the laboratory of Dr. Richard B. Rothman. From 1991-2011, Mike and his colleagues elucidated the critical role of brain dopamine and serotonin in the mechanism of action for various therapeutic and abused stimulant drugs. While working with Dr. Rothman, Mike was promoted to Senior Staff Fellow, Research Biologist, and finally to his current position as Staff Scientist. He joined the laboratory of Dr. Newman in 2012 and established the Designer Drug Research Unit (DDRU). The main goals of the DDRU are to collect, analyze and disseminate current information about the pharmacology and toxicology of newly-emerging synthetic drugs of abuse (i.e., designer drugs). Working with partner organizations such as the Drug Enforcement Administration (DEA) and the Community Epidemiology Work Group (CEWG), Mike is kept informed about recent trends in designer drug use. Most recently, his laboratory has determined the molecular mechanism of action for several so-called “bath salts” cathinones.

Selected Publications

  • Baumann, M.H., Clark, R.D., Woolverton, W.L., Wee, S., Blough, B.E. and Rothman, R.B. (2011) In vivo effects of amphetamine analogs reveal evidence for serotonergic inhibition of mesolimbic dopamine transmission in the rat. J.Pharmacol. Exp. Ther. 337:218-225.
  • Baumann, M.H., Ayestas, M.A., Partilla, J.S., Sink, J.L., Shulgin, A.T., Daley, P.F., Brandt, S.D., Rothman, R.B., Ruoho, A.E. and Cozzi, N.V. (2012) The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. Neuropsychopharmacology 37:1192-1203.
  • Yubero-Lahoz, S., Ayestas, Jr., M.A., Blough, B.E., Partilla, J.S., Rothman, R.B., de la Torre, R. and Baumann, M.H. (2012) Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain. Eur. J. Pharmacol. 674:337-344.
  • Baumann, M.H., Partilla, J.S. and Lehner, K.R. (2013) Psychoactive “bath salts”: Not so soothing. Eur. J. Pharmacol. 698:1-5.
  • Baumann, M.H., Partilla, J.S., Lehner, K.R., Thorndike, E.B., Hoffman, A.F., Holy, M., Rothman, R.B., Goldberg, S.R., Lupica, C.R., Sitte, H.H., Brandt, S.D., Tella, S.R., Cozzi, N.V. and Schindler, C.R. (2013) Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive “bath salts” products. Neuropsychopharmacology 38:552-562.