The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Yihong Yang, Ph.D., Senior Investigator and Chief ofMagnetic Resonance Imaging and Spectroscopy Section, National Institute on Drug Abuse, National Institutes of Health to its College of Fellows. Dr. Yang was nominated, reviewed, and elected by peers and members of the College… [Read More]
Discovery and development of varenicline for smoking cessation
Reviews To Read – April 3, 2018. from the Addiction Biology Unit Quitting smoking is challenging. The recent development of varenicline (Chantix®) for smoking cessation is a successful story. In this article, we review the strong theoretical rationale, major findings in preclinical and clinical studies with varenicline, and post-market surveillance. We also discuss current major… [Read More]
Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission.
Featured Paper of the Month – April 2018. The lateral habenula (LHb) is a brain structure that participates in cognitive and emotional processing and has been implicated in several mental disorders. Although one of the largest inputs to the LHb originates in the lateral preoptic area (LPO), little is known about how the LPO participates… [Read More]
2018 NIDA IRP Women Scientist Advisors Awards
The NIDA IRP Women Scientist Advisors awards ceremony is held annually to recognize the accomplishments of outstanding women scientists. The 2018 awardees are: Elisabeth de Castro Caparelli – Staff Scientist Melissa Sharpe – Postdoctoral Fellow Congratulations to this years winners! Click here to learn more about the Woman Scientist Advisors (WSA) and see previous winners.
NIDA IRP presents awards at the 2018 Baltimore Science Fair
The Baltimore Science Fair was held this past weekend at Towson University. Over 100 middle school and high school students from Baltimore City, Baltimore, Carrol, Cecil, Harford, and Howard Counties participated, spending many hours on Saturday describing their work to a LOT of judges. Judges came from all over, including FDA, other NIH institutes, US… [Read More]
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
Hot Off the Press – March 28, 2018. Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body’s hard-working G protein-coupled receptors (GPCRs) than previously thought, suggesting a conceptual advance in the fields of biochemistry and pharmacology. With… [Read More]
2018 Patient Safety Awareness Week
The staff of the NIDA IRP Office of the Clinical Director celebrated 2018 Patient Safety Awareness Week March 11-17 by pledging to make patient saftey a top priority and decorating our clinics with reminders of the campaign. New comment boxes were also installed throughout the clinic so patients and staff can anonymously report concerns. All… [Read More]
Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals.
Featured Paper of the Month – March 2018. Understanding the neurobiological substrates of excessive alcohol consumption may substantially facilitate efforts to develop better treatments. The cross-talk between the gastrointestinal and central nervous systems, often referred to as the gut–brain axis, is a promising yet underexplored domain in this regard. Ghrelin is a hormone primarily produced… [Read More]
Misuse of Novel Synthetic Opioids: A Deadly New Trend.
Reviews To Read – March 1, 2018. The United States is experiencing an epidemic of opioid overdose deaths. A major factor in this crisis is the increasing availability of potent opioid drugs, including fentanyl and novel synthetic opioids (NSOs). NSOs include various analogs of fentanyl and newly-emerging non-fentanyl compounds which stimulate mu-opioid receptor proteins in… [Read More]
Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor.
Hot Off the Press – February 15, 2018. The two highly homologous subtypes of stimulatory G proteins Gαs (Gs) and Gαolf (Golf) display contrasting expression patterns in the brain. Golf is predominant in the striatum, while Gs is predominant in the cortex. Yet, little is known about their functional distinctions. The dopamineD1 receptor (D1R) couples to Gs/olf and is highly expressed in cortical… [Read More]
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