Featured Paper of the Month – March 2018. Understanding the neurobiological substrates of excessive alcohol consumption may substantially facilitate efforts to develop better treatments. The cross-talk between the gastrointestinal and central nervous systems, often referred to as the gut–brain axis, is a promising yet underexplored domain in this regard. Ghrelin is a hormone primarily produced… [Read More]
Reviews To Read – November 3, 2017
Prekupec, Matthew P; Mansky, Peter A; Baumann, Michael H
J Addict Med, 11 (7), pp. 256–265, 2017.
Hot Off the Press – February 15, 2018. The two highly homologous subtypes of stimulatory G proteins Gαs (Gs) and Gαolf (Golf) display contrasting expression patterns in the brain. Golf is predominant in the striatum, while Gs is predominant in the cortex. Yet, little is known about their functional distinctions. The dopamineD1 receptor (D1R) couples to Gs/olf and is highly expressed in cortical… [Read More]
Featured Paper of the Month – February 2018. Learned associations between environmental stimuli and rewards drive learning and motivated behavior. These memories are thought to be encoded by alterations within specific patterns of sparsely distributed neurons called neuronal ensembles that are selectively activated by reward-predictive stimuli. Here we use the Fos promoter to identify strongly… [Read More]
Hot Off the Press! – January 2018. Associative learning is driven by fundamental instructive or teaching signals that reflect errors in the prediction of rewards and other events. Previously dopamine neurons in the midbrain that project widely in the brain have been shown to signal these errors only for value. Here NIDA researchers show that… [Read More]
Reviews To Read – January 3, 2018. From the NIDA IRP Real World Assessment, Prediction and Treatment Unit. In this invited commentary, Bill Kowalczyk and I weighed in on a new rat model of addiction developed by Chiara Giuliano in Barry Everitt’s lab at the University of Cambridge. Like other recently developed models of addiction,… [Read More]
Featured Paper of the Month – January 2018. From the NIDA IRP Molecular Mechanisms of Cellular Stress and Inflammation Section The endoplasmic reticulum (ER) is cellular organelle that performs critical functions such as the production and processing of proteins, lipids and drugs. The ER also serves as the primary storage site for calcium inside the cell. … [Read More]
Dr. Kenner Rice from the National Institute on Drug Abuse’s (NIDA) Intramural Research Program (IRP) was recently named as a 2017 Fellow of the National Academy of Inventors (NAI). This is the highest professional accolade bestowed to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have… [Read More]
Featured Paper of the Month – December 2017. The etiology and pathophysiology of drug addiction are still not well understood. In this research paper, we show that genetic deletion of mGluR2, a presynaptic glutamate autoreceptor, decreases sensitivity to cocaine reward that causes a compensatory increase in cocaine intake and a decrease in relapse to cocaine-seeking… [Read More]
Reviews To Read – November 20, 2017
Panlilio, Leigh V; Justinova, Zuzana
Neuropsychopharmacology. 2017 Aug 28.