IRP News

Baltimore Science Fair Success!

The IRP’s Diversity and Outreach Committee (DOC) represented the NIDA IRP again at the Baltimore Science Fair held at Towson University over the weekend of March 23rd and 24th. Over 100 middle school and high school students from Baltimore City, Baltimore, Carrol, Cecil, Harford, and Howard Counties participated, spending many hours on Saturday describing their… [Read More]

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Hot Off the Press

Ultrapotent chemogenetics for research and potential clinical applications.

Hot Off the Press – April 12, 2019. NIDA-funded scientists have just published findings in the journal Science showing the development of a new, groundbreaking chemogenetics technology for modulating brain function in a remote, precise and ultra-sensitive manner in living subjects. These findings describe new chemogenetic ion channels for neuron activation and silencing that are controlled by… [Read More]

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Reviews To Read

Expression of immediate early genes in brain reward circuitries: Differential regulation by psychostimulant and opioid drugs.

Reviews To Read – January 2019. Although some of the clinical manifestations of substance use disorders might be superficially similar, it is highly likely that different classes of abused drugs including opioids (heroin, morphine, and oxycodone, other opioids) and psychostimulants (cocaine and amphetamines) cause different neuroadaptations in various brain regions dependent in the distribution and concentration of their biochemical… [Read More]

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Featured Papers

Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects.

Featured Paper of the Month – April 2019. Opioid use disorders are currently a serious health problem worldwide and yet prescription opioids remain as the most effective medications to treat pain. VK4-116, a highly selective dopamine D3 receptor antagonist, significantly inhibited acquisition of oxycodone self-administration behaviors and decreased oxycodone seeking in several rodent models. VK4-116… [Read More]

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