IRP News

Navigating Your Life Without Losing Yourself

Tuesday June 19, 2018 • 2 – 3 pm in the BRC Atrium Panel discussion on mental health in college & career Topics will include: Self-identity Managing recovery Managing stress and workload Warning signs Seeking support and help Mentoring students Supporting marginalized students Advocating for yourself Bring your questions for the panelists or submit anonymously via… [Read More]

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Hot Off the Press

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor.

Hot Off the Press – February 15, 2018. The two highly homologous subtypes of stimulatory G proteins Gαs (Gs) and Gαolf (Golf) display contrasting expression patterns in the brain. Golf is predominant in the striatum, while Gs is predominant in the cortex. Yet, little is known about their functional distinctions. The dopamineD1 receptor (D1R) couples to Gs/olf and is highly expressed in cortical… [Read More]

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Reviews To Read

Discovery and development of varenicline for smoking cessation

Reviews To Read – April 3, 2018. from the Addiction Biology Unit Quitting smoking is challenging. The recent development of varenicline (Chantix®) for smoking cessation is a successful story.  In this article, we review the strong theoretical rationale, major findings in preclinical and clinical studies with varenicline, and post-market surveillance. We also discuss current major… [Read More]

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Featured Papers

Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task.

Featured Paper of the Month – July 2018. Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation of… [Read More]

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