IRP News

Lorenzo Leggio given the ACNP Eva King-Killam Research Award

The American College of Neuropsychopharmacology (ACNP) has named Lorenzo Leggio, M.D., Ph.D. as the winner of the Eva King-Killam Research Award.  Dr. Leggio is a Clinical Investigator and Section Chief for the NIAAA and NIDA Intramural Research Programs (IRPs). He also serves as Associate Director for Clinical Research for the NIDA IRP Medication Development Program…. [Read More]

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Hot Off the Press

Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice.

Hot Off the Press – November 29, 2018. The neural mechanisms underlying dopamine neuron degeneration in Parkinson’s disease are largely unknown. In this study, we found that selective deletion of a vesicular glutamate transporter (VgluT2) in dopamine neurons led to a significant increase in dopamine neuron toxicity to the neurotoxin MPTP via a BDNF-dependent mechanism,… [Read More]

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Reviews To Read

Expression of immediate early genes in brain reward circuitries: Differential regulation by psychostimulant and opioid drugs.

Reviews To Read – January 2019. Although some of the clinical manifestations of substance use disorders might be superficially similar, it is highly likely that different classes of abused drugs including opioids (heroin, morphine, and oxycodone, other opioids) and psychostimulants (cocaine and amphetamines) cause different neuroadaptations in various brain regions dependent in the distribution and concentration of their biochemical… [Read More]

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