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Sigma-1 receptor chaperones rescue nucleocytoplasmic transport deficit seen in cellular and Drosophila ALS/FTD models

Hot Off the Press – February 9, 2021 A receptor called the sigma-1 receptor, which was discovered at NIDA IRP, plays an important role in regulating the cargo transport between the cellular nucleus and cytoplasm that is dysfunctional in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The authors demonstrate and validate… [Read More]

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