Hot Off the Press – October 25, 2018. There are currently no effective medications available for the treatment of psychostimulant addiction. Receptor-type protein tyrosine phosphatase D (PTPRD) is a neuronal cell-adhesion molecule that has been associated with psychostimulant addiction in humans. In this research, we found that PTPRD gene mutation significantly reduced vulnerability to cocaine… [Read More]
Hot Off the Press – October 10, 2018. Using miniature fluorescence microscopes (miniScope) via an implanted optical microprobe, Liang and Zhang et. al. were able to record the calcium activity from hundreds of nerve cells in medial prefrontal cortex (mPFC) when the mice freely engaged in social exploration. They track the activity of the same… [Read More]
Hot Off the Press – March 28, 2018. Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body’s hard-working G protein-coupled receptors (GPCRs) than previously thought, suggesting a conceptual advance in the fields of biochemistry and pharmacology. With… [Read More]
Hot Off the Press – February 15, 2018. The two highly homologous subtypes of stimulatory G proteins Gαs (Gs) and Gαolf (Golf) display contrasting expression patterns in the brain. Golf is predominant in the striatum, while Gs is predominant in the cortex. Yet, little is known about their functional distinctions. The dopamineD1 receptor (D1R) couples to Gs/olf and is highly expressed in cortical… [Read More]
Hot Off the Press! – January 2018. Associative learning is driven by fundamental instructive or teaching signals that reflect errors in the prediction of rewards and other events. Previously dopamine neurons in the midbrain that project widely in the brain have been shown to signal these errors only for value. Here NIDA researchers show that… [Read More]
Hot Off the Press! – October 2017
Venniro, Marco; Caprioli, Daniele; Zhang, Michelle; Whitaker, Leslie R; Zhang, Shiliang; Warren, Brandon L; Cifani, Carlo; Marchant, Nathan J; Yizhar, Ofer; Bossert, Jennifer M; Chiamulera, Cristiano; Morales, Marisela; Shaham, Yavin
Neuron, 96 (2), pp. 414–427, 2017, ISSN: 1097-4199 (Electronic); 0896-6273 (Linking).
Hot Off the Press! – August 2017
Gomez, Juan L; Bonaventura, Jordi; Lesniak, Wojciech; Mathews, William B; Sysa-Shah, Polina; Rodriguez, Lionel A; Ellis, Randall J; Richie, Christopher T; Harvey, Brandon K; Dannals, Robert F; Pomper, Martin G; Bonci, Antonello; Michaelides, Michael
Science, 357 (6350), pp. 503–507, 2017, ISSN: 1095-9203 (Electronic); 0036-8075 (Linking).
Hot Off the Press! – July 2017
Biase, Lindsay De M; Schuebel, Kornel E; Fusfeld, Zachary H; Jair, Kamwing; Hawes, Isobel A; Cimbro, Raffaello; Zhang, Hai-Ying; Liu, Qing-Rong; Shen, Hui; Xi, Zheng-Xiong; Goldman, David; Bonci, Antonello
Neuron, 95 (2), pp. 341–356, 2017, ISSN: 1097-4199 (Electronic); 0896-6273 (Linking).
Hot Off the Press! – June 2017
Lesage, Elise; Aronson, Sarah E; Sutherland, Matthew T; Ross, Thomas J; Salmeron, Betty Jo; Stein, Elliot A
JAMA Psychiatry, 74 (6), pp. 632–640, 2017, ISSN: 2168-6238 (Electronic); 2168-622X (Linking).
Hot Off The Press – April 2017
Sharpe, Melissa J; Chang, Chun Yun; Liu, Melissa A; Batchelor, Hannah M; Mueller, Lauren E; Jones, Joshua L; Niv, Yael; Schoenbaum, Geoffrey
Nat Neurosci, 20 (5), pp. 735–742, 2017, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).