Jean Lud Cadet, M.D., Senior Investigator - Principal Investigators - The Intramural Research Program of the National Institute on Drug Abuse

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PRINCIPAL INVESTIGATORS

photo of Dr. Cadet

CONTACT ME

NIDA IRP
251 Bayview Boulevard
Suite 200, Room 07A721A
Baltimore MD 21224

Phone: 443-740-2656
Fax: 443-740-2856

jcadet@intra.nida.nih.gov

Jean Lud Cadet, M.D., Senior Investigator

Chief, Molecular Neuropsychiatry Research Branch
Associate Director for Diversity and Outreach

M.D. - Columbia University College of Physicians and Surgeons

Residencies
- Department of Psychiatry at Columbia University College of Physicians and Surgeons
- Department of Neurology at Mount Sinai Medical Center in NYC

Post-Doctoral Fellowship - Neuropsychiatry Branch, NIMH

RESEARCH INTERESTS

Research in our section focuses on studies the molecular and cellular mechanisms of psychostimulant addiction and toxicity. Dr. Cadet’s group has provided recent evidence that methamphetamine (METH) self-administration is accompanied with markers of toxicity in striatal dopaminergic systems. These results are consistent with the idea that catecholamines, especially, dopamine can activate neurodegenerative processes in the mammalian brain. We have also shown recently that METH preconditioning protects against METH toxicity. This occurs by upregulation of neurotrophic factors such as BDNF and/or downregulation of glutamatergic systems. Preliminary studies have shown that these changes are secondary to epigenetic modifications that include histone hypoacetylation and DNA methylation. The laboratory is thus pursuing investigations to further identify epigenetic markers that are involved in METH self-administration and METH preconditioning.

Selected Publications:

View more publications at PubMed.

About Dr. Cadet's...

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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