Reviews To Read – September 2017
Weng, Tzu-Yu; Tsai, Shang-Yi Anne; Su, Tsung
J Biomed Sci, 24 (1), pp. 74, 2017, ISSN: 1423-0127 (Electronic); 1021-7770 (Linking).
Read More…
Archives for 2017
Salience and default mode network dysregulation in chronic cocaine users predict treatment outcome.
Featured Paper of the Month – September 2017
Published in Brain by Geng, Xiujuan; Hu, Yuzheng; Gu, Hong; Salmeron, Betty Jo; Adinoff, Bryon; Stein, Elliot A; Yang, Yihong
While chronic cocaine use is associated with abnormalities in both brain structure and function within and interactions between regions, previous studies have been limited to interrogating structure and function independently, and the detected neural differences have not been applied to independent samples to assess the clinical relevance of results…
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.
Hot Off the Press! – August 2017
Gomez, Juan L; Bonaventura, Jordi; Lesniak, Wojciech; Mathews, William B; Sysa-Shah, Polina; Rodriguez, Lionel A; Ellis, Randall J; Richie, Christopher T; Harvey, Brandon K; Dannals, Robert F; Pomper, Martin G; Bonci, Antonello; Michaelides, Michael
Science, 357 (6350), pp. 503–507, 2017, ISSN: 1095-9203 (Electronic); 0036-8075 (Linking).
[Read More]
New paper published in Science!
August 3, 2017 Chemogenetics revealed: DREADD occupancy and activation via converted clozapine Click here for article on Science site.
The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.
Featured Paper of the Month – August 2017
Published in Neuropsychopharmacology by Zhang, Hai-Ying; Bi, Guo-Hua; Yang, Hong-Ju; He, Yi; Xue, Gilbert; Cao, Jiajing; Tanda, Gianluigi; Gardner, Eliot L; Newman, Amy Hauck; Xi, Zheng-Xiong
(+/-)Modafinil ((+/-)MOD) and its R-enantiomer (R-modafinil; R-MOD) have been investigated for their potential as treatments for psychostimulant addiction. We recently reported a series of (+/-)MOD analogs, of which JJC8-016 (N-(2-((bis(4-fluorophenyl)methyl)thio)ethyl)-3-phenylpropan-1-amine) was selected for further development. JJC8-016 and R-MOD were evaluated for binding across ~70 receptors, transporters, and enzymes…
Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.
Hot Off the Press! – July 2017
Biase, Lindsay De M; Schuebel, Kornel E; Fusfeld, Zachary H; Jair, Kamwing; Hawes, Isobel A; Cimbro, Raffaello; Zhang, Hai-Ying; Liu, Qing-Rong; Shen, Hui; Xi, Zheng-Xiong; Goldman, David; Bonci, Antonello
Neuron, 95 (2), pp. 341–356, 2017, ISSN: 1097-4199 (Electronic); 0896-6273 (Linking).
[Read More]
Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).
Featured Paper of the Month – July 2017
Published in The Journal of Medical Chemistry by Kumar, Vivek; Moritz, Amy E; Keck, Thomas M; Bonifazi, Alessandro; Ellenberger, Michael P; Sibley, Christopher D; Free, Benjamin R; Shi, Lei; Lane, Robert J; Sibley, David R; Newman, Amy Hauck
The development of bitopic ligands directed toward D2-like receptors has proven to be of particular interest to improve the selectivity and/or affinity of these ligands and as an approach to modulate and bias their efficacies. The structural similarities between dopamine D3 receptor (D3R)-selective molecules that display bitopic or allosteric pharmacology and those that are simply competitive antagonists are subtle and intriguing…
New paper published!
June 5, 2017 Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic-Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement Click here for article on Neuropsychopharmacology site.
Welcome to the lab Sherry Lam, Kelsey Wright and Dondre Marable!!
June 4, 2017
Ventral tegmental area: cellular heterogeneity, connectivity and behaviour.
Reviews To Read – June 2017
Morales, Marisela; Margolis, Elyssa B
Nat Rev Neurosci, 18 (2), pp. 73–85, 2017, ISSN: 1471-0048 (Electronic); 1471-003X (Linking).
[Read More]