Osama Abulseoud, M.D.

@article{Gibson2017,

title = {The Impact of Mirth-Inducing Ventral Striatal Deep Brain Stimulation on Functional and Effective Connectivity},

author = {William S Gibson and Shinho Cho and Osama A Abulseoud and Krzysztof R Gorny and Joel P Felmlee and Kirk M Welker and Bryan T Klassen and Hoon-Ki Min and Kendall H Lee},

url = {https://academic.oup.com/cercor/article/27/3/2183/3056326},

doi = {10.1093/cercor/bhw074},

year  = {2017},

date = {2017-01-01},

journal = {Cerebral Cortex},

volume = {27},

number = {3},

pages = {2183-2194},

abstract = {Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is an investigational therapy for treatment-resistant obsessive-compulsive disorder. The ability of VC/VS DBS to evoke spontaneous mirth in patients, often accompanied by smiling and laughter, is clinically well documented. However, the neural correlates of DBS-evoked mirth remain poorly characterized. Patients undergoing VC/VS DBS surgery underwent intraoperative evaluation in which mirth-inducing and non-mirth-inducing stimulation localizations were identified. Using dynamic causal modeling (DCM) for fMRI, the effect of mirth-inducing DBS on functional and effective connectivity among established nodes in limbic cortico-striato-thalamo-cortical (CSTC) circuitry was investigated. Both mirth-inducing and non-mirth-inducing VC/VS DBS consistently resulted (conjunction, global null, family-wise error-corrected P < 0.05) in activation of amygdala, ventral striatum, and mediodorsal thalamus. However, only mirth-inducing DBS resulted in functional inhibition of anterior cingulate cortex. Dynamic causal modeling revealed that mirth-inducing DBS enhanced effective connectivity from anterior cingulate to ventral striatum, while attenuating connectivity from thalamus to ventral striatum relative to non-mirth-inducing stimulation. These results suggest that DBS-evoked mood elevation is accompanied by distinct patterns of limbic thalamocortical connectivity. Using the novel combination of DBS-evoked mood alteration and functional MRI in human subjects, we provide new insights into the network-level mechanisms that influence affect.},

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pubstate = {published},

tppubtype = {article}

}

@article{Abulseoud2016,

title = {Stimulation-Induced Transient Nonmotor Psychiatric Symptoms following Subthalamic Deep Brain Stimulation in Patients with Parkinson's Disease: Association with Clinical Outcomes and Neuroanatomical Correlates.},

author = {Osama A Abulseoud and Aimen Kasasbeh and Hoon-Ki Min and Julie A Fields and Susannah J Tye and Stephan Goerss and Emily J Knight and Shirlene M Sampson and Bryan T Klassen and Joseph Y Matsumoto and Cynthia Stoppel and Kendall H Lee and Mark A Frye},

url = {https://www.ncbi.nlm.nih.gov/pubmed/27093641},

doi = {10.1159/000445076},

issn = {1423-0372 (Electronic); 1011-6125 (Linking)},

year  = {2016},

date = {2016-04-20},

journal = {Stereotact Funct Neurosurg},

volume = {94},

number = {2},

pages = {93--101},

address = {Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn., USA.},

abstract = {BACKGROUND: The clinical and neurobiological underpinnings of transient nonmotor (TNM) psychiatric symptoms during the optimization of stimulation parameters in the course of subthalamic nucleus deep brain stimulation (STN-DBS) remain under intense investigation. METHODS: Forty-nine patients with refractory Parkinson's disease underwent bilateral STN-DBS implants and were enrolled in a 24-week prospective, naturalistic follow-up study. Patients who exhibited TNM psychiatric manifestations during DBS parameter optimization were evaluated for potential associations with clinical outcome measures. RESULTS: Twenty-nine TNM+ episodes were reported by 15 patients. No differences between TNM+ and TNM- groups were found in motor outcome. However, unlike the TNM- group, TNM+ patients did not report improvement in subsyndromal depression or quality of life. TNM+ episodes were more likely to emerge during bilateral monopolar stimulation of the medial STN. CONCLUSIONS: The occurrence of TNM psychiatric symptoms during optimization of stimulation parameters was associated with the persistence of subsyndromal depression and with lower quality of life ratings at 6 months. The neurobiological underpinnings of TNM symptoms are investigated yet remain difficult to explain.},

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pubstate = {published},

tppubtype = {article}

}

@article{Abulseoud2015,

title = {Sex differences in mania phenotype and ethanol consumption in the lateral hypothalamic kindled rat model.},

author = {O A Abulseoud and N A Gawad and K Mohamed and C Vadnie and U M Camsari and V Karpyak and M A Frye and D-S Choi},

url = {https://www.ncbi.nlm.nih.gov/pubmed/25803497},

doi = {10.1038/tp.2015.30},

issn = {2158-3188 (Electronic); 2158-3188 (Linking)},

year  = {2015},

date = {2015-03-24},

journal = {Transl Psychiatry},

volume = {5},

pages = {e534},

address = {Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.},

abstract = {Sex differences have been observed in mania phenotypes in humans. However the mechanisms underlying this difference are poorly understood. Activating the lateral hypothalamus is implicated in manic-like behaviors in rodents. Using newly established lateral hypothalamus kindled (LHK) rat mania model, we investigated sex differences of manic-like behaviors and its correlation with voluntary ethanol intake. We stimulated the lateral hypothalamus bilaterally in the male and female Wistar rats over five consecutive days. We recorded and quantified kindling-induced behaviors for each individual animal. We also assessed ethanol consumption using a two-bottle choice ethanol drinking as well as circadian locomotor activity counts daily throughout the experiment. We found notable sex differences in several aspects of manic-like behaviors during kindling. Males exhibited a significantly increased locomotor activity during the light phase, and reduced rest interval. On the other hand, females displayed significantly higher ethanol consumption and more frequent rearing behavior. However, no sex differences were present in the duration of sexual, feeding or grooming behaviors or in dark-phase activity counts. The excessive alcohol intake in LHK female rats is reminiscent of clinically reported sex differences in bipolar patients while the other phenotypic sex differences such as rearing and locomotor activity are less clearly described in clinical studies. Overall, our results lend further evidence for the validity of the LHK rat as a useful model to study brain region-specific molecular changes during mania and its correlation with alcohol use disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hitschfeld2015,

title = {Female smokers have the highest alcohol craving in a residential alcoholism treatment cohort.},

author = {Mario J Hitschfeld and Terry D Schneekloth and Jon O Ebbert and Daniel K Hall-Flavin and Victor M Karpyak and Osama A Abulseoud and Christi A Patten and Jennifer R Geske and Mark A Frye},

url = {https://www.ncbi.nlm.nih.gov/pubmed/25746235},

doi = {10.1016/j.drugalcdep.2015.02.016},

issn = {1879-0046 (Electronic); 0376-8716 (Linking)},

year  = {2015},

date = {2015-02-25},

journal = {Drug Alcohol Depend},

volume = {150},

pages = {179--182},

address = {Department of Psychiatry & Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA; Mental Health Service, Sotero Del Rio Hospital, Avenida Concha y Toro 3459, Puente Alto, Santiago, Chile.},

abstract = {BACKGROUND: Cigarette smoking among female and male alcoholics has not been extensively studied as a factor related to intensity of alcohol craving during residential treatment and corresponding sobriety length. METHODS: This retrospective cohort study assessed self-reported sobriety outcomes in patients with alcohol dependence at 3-month intervals over 12 months after completion of a 30-day residential treatment program. Demographic and clinical variables were collected including smoking status, alcohol craving utilizing the Penn Alcohol Craving Scale (PACS), and alcohol relapse. Statistical analyses included Chi-square, ANOVA, Tukey's test, Kaplan-Meier plots and Cox proportional hazards models as appropriate. RESULTS: Of the 761 alcohol-dependent study subjects, 355 (47%) were current smokers. Alcohol craving intensity was higher in smoking females compared to nonsmoking females (p=0.0096), smoking males (p<0.0001), and nonsmoking males (p<0.0001). Smoking status-by-sex interaction was not associated with post-treatment relapse. After controlling for other variables, higher PACS scores at admission were associated with higher probability of relapse (p=0.0003). CONCLUSIONS: In this study, female alcoholic smokers experienced the highest level of alcohol craving in an alcohol treatment setting. Interestingly, this did not translate into higher rates of post-treatment relapse. Further research is warranted to explore the neurobiological basis for sex differences in this highly prevalent comorbidity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Cuellar-Barboza2014,

title = {Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery.},

author = {Alfredo B Cuellar-Barboza and Mark A Frye and Karen Grothe and Miguel L Prieto and Terry D Schneekloth and Larissa L Loukianova and Daniel K Hall-Flavin and Matthew M Clark and Victor M Karpyak and Joseph D Miller and Osama A Abulseoud},

url = {https://www.ncbi.nlm.nih.gov/pubmed/25258356},

doi = {10.1016/j.jpsychores.2014.06.019},

issn = {1879-1360 (Electronic); 0022-3999 (Linking)},

year  = {2014},

date = {2014-09-07},

journal = {J Psychosom Res},

volume = {78},

number = {3},

pages = {199--204},

address = {Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States; Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.},

abstract = {OBJECTIVE: The aim of this study is to describe the clinical phenotype of alcohol use disorder (AUD) treatment-seeking patients with Roux-en-Y Gastric Bypass Surgery (RYGB) history; and to compare it to AUD obese non-RYGB controls. METHODS: Retrospective study of electronic medical records for all patients 30-60years treated at the Mayo Clinic Addiction Treatment Program, between June, 2004 and July, 2012. Comparisons were performed with consumption patterns pre-RYGB and at time of treatment; excluding patients with AUD treatments pre-RYGB. RESULTS: Forty-one out of 823 patients had a RYGB history (4.9%); 122 controls were selected. Compared to controls, the RYGB group had significantly more females [n=29 (70.7%) vs. n=35 (28.7%) p<0.0001]; and met AUD criteria at a significantly earlier age (19.1+/-0.4 vs. 25.0+/-1years old},

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pubstate = {published},

tppubtype = {article}

}

@article{Abulseoud2014b,

title = {Lateral hypothalamic kindling induces manic-like behavior in rats: a novel animal model.},

author = {Osama A Abulseoud and Ulas M Camsari and Christina L Ruby and Khalid Mohamed and Noha M Abdel Gawad and Aimen Kasasbeh and Mehmet Y Yuksel and Doo-Sup Choi},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26092394},

doi = {10.1186/s40345-014-0007-8},

issn = {2194-7511 (Print); 2194-7511 (Linking)},

year  = {2014},

date = {2014-06-14},

journal = {Int J Bipolar Disord},

volume = {2},

number = {1},

pages = {7},

address = {Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA, Abulseoud.Osama@mayo.edu.},

abstract = {The lateral hypothalamus integrates critical physiological functions such as the sleep-wake cycle, energy expenditure, and sexual behaviors. These functions are severely dysregulated during mania. In this study, we successfully induced manic-like behavioral phenotypes in adult, male Wistar rats through bilateral lateral hypothalamic area kindling (LHK). To test the validity of the model, we studied the effect of standard antimanic medications lithium (47.5 mg/kg) or valproic acid (200 mg/kg) twice/day for 15 days in attenuating manic-like behaviors in the LHK rat. Compared with pre-kindling behaviors, LHK rats displayed significantly increased sexual self-stimulation (P = 0.034), excessive rearing (P = 0.0005), feeding (P = 0.013), and grooming (P = 0.007) during the kindling interval. LHK rats also drank more alcohol during the mania-induction days compared with baseline ethanol consumption levels (P = 0.01). Moreover, LHK rat exhibited increased total locomotor activity (P = 0.02) with reduced rest interval (P < 0.001) during the mania induction and post-mania days compared with baseline activity levels and rest intervals. Chronic administration of lithium or valproic acid significantly attenuated manic-like behaviors in the LHK rat model. Given the behavioral phenotype and the response to standard antimanic medications, the LHK rats may provide a model for studying manic psychopathology in humans.},

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pubstate = {published},

tppubtype = {article}

}