NIDA IRP Core Facilities

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NIDA IRP CORE FACILITIES

Cores Director: Marisela Morales, Ph.D. on-site page link


NIDA IRP Electron Microscopy Core

Mission: The NIDA Electron Microscopy (EM) Core serves NIDA-IRP researchers by providing access to existing and emerging techniques for neuronal ultrastructural analysis.

Services: The NIDA EM Core offers the following services:

  • EM services that are tailored to the needs of individual IRP researchers. Services include sectioning, immunostaining and counterstaining, and EM imaging.
  • Training and access to an ultrathin microtome and a transmission electron microscope, and data interpretation.

Contact information:


NIDA IRP Genetic Engineering and Viral Vector Core

Mission: The NIDA Genetic Engineering and Viral Vector Core (GE&VVC) serves NIDA-IRP researchers by facilitating studies of brain function under physiological and pathological conditions through developing and producing genetic tools capable of modulating and monitoring the molecules, cells and circuits in the nervous system.

Services: The NIDA GE&VVC offers the following services:

  • GE&VVC services that are tailored to the needs of individual IRP researchers. Services include plasmid construction, packaging of custom Adeno-associated virus (AAV) and Lentivirus (LV) vectors, genome editing consultation for the design of CRISPR reagents for targeted mutagenesis or knock-in transgenes, development of genotyping assays, and BAC recombineering.
  • Training and access to equipment necessary for molecular biology techniques, i.e. for the construction of DNA vectors, genotyping, quantification of gene expression by ddPCR and qRT-PCR, expression and purification of proteins in bacterial and mammalian cell culture.

Contact information:

  • Christopher Richie, Ph.D., Manager, chrisr@nida.nih.gov
  • For Transgenic Rat Project under OTTC, please click HERE.

NIDA IRP Histology Core

Mission: The NIDA Histology Core serves NIDA-IRP researchers by providing access to existing and emerging neuroanatomical technologies.

Services: The NIDA Histology Core offers the following services:

  • Histology services that are tailored to the needs of individual IRP researchers. Services include sectioning, immunostaining and counterstaining, whole-brain serial tomography, and imaging of cleared sample using light-sheet microscopy.
  • Training and access to different types of microscopes, 2 cryostats, one vibratome, and computers for image analysis.

Contact information:


NIDA IRP Structural Biology Core

Mission: The NIDA Structural Biology Core serves NIDA-IRP researchers by providing state-of-the-art techniques in mass spectrometry to determine the presence, distribution, and amounts of molecules in biological samples.

Services: The NIDA Structural Biology Core offers the following services:

  • The Structural Biology Core services are tailored to the needs of individual IRP researchers. Services include providing exact mass measurements; structural identification of drugs, metabolites, lipids and peptides; global lipidomic analysis and mass spectrometry imaging.
  • Training and access to different types of mass spectrometers and computers for data analysis.

Contact information:

Related Information...

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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