A division of the Translational Addiction Medicine Branch
A joint National Institute on Drug Abuse (NIDA) and National Institute on Alcohol Abuse and Alcoholism (NIAAA) Laboratory
Biomedical Research Center
251 Bayview Boulevard
Suite 200, Room 01A844
Baltimore, MD 21224
About the Lab
Dr. Leggio’s CPN laboratory conducts clinical and translational inpatient and outpatient studies to identify possible novel medications for addiction. His group uses a combination of state-of-the-art, innovative bio behavioral and pharmacological procedures performed under well-controlled human laboratory conditions. Imaging brain techniques, such as fMRI and PET, are also employed. Dr. Leggio and his team are particularly interested in the role of the gut-liver-brain axis in alcohol- and drug-seeking behaviors. Specifically, the CPN laboratory is currently investigating the potential role of feeding-related pathways, such as ghrelin, leptin, oxytocin and GLP-1, as possible new neuropharmacological targets for the treatment of alcohol and substance use disorders. Other neuroendocrine pathways are also under investigation, such as the aldosterone / mineralocorticoid receptor pathway. The CPN laboratory has recently expanded its research looking at the role of the gut microbiota in heavy drinkers with a special emphasis on the relationships between alcohol-related seeking behaviors and the microbiota-gut-brain axis. Future research includes work on the effects of bariatric surgery on alcohol-related seeking behaviors. Both preclinical and human approaches are under development to shed light on the possible role of these pathways in alcohol and substance use disorders.