A division of the Neuroimaging Research Branch
Biomedical Research Center
251 Bayview Blvd
Suite 200, Room 07A709
Baltimore, MD 21224
About the Lab
The Magnetic Resonance Imaging and Spectroscopy Section pursues the following objectives:
- To develop functional magnetic resonance imaging (fMRI) techniques to measure evoked and resting activity of the brain. In evoked-fMRI, brain activation is detected using multiple parameters that provide complementary and quantitative measurements. In resting-state fMRI, new acquisition and analysis strategies are being developed to assess alterations of brain circuitry in drug users.
- To investigate structural MRI techniques used to assess tissue integrity related to brain dysfunction. Diffusion tensor imaging (DTI) and beyond DTI techniques are being developed to examine microstructural changes in white and gray matter, and fiber bundles delineated by tractography techniques. Novel image registration methods based on an implicit reference are being developed for more accurate group analysis. We are also developing voxelwise methods to evaluate structural changes in the brain, and evaluating these methods in substance abuse populations.
- To develop magnetic resonance spectroscopy (MRS) techniques to measure metabolite and neurotransmitter concentrations in the brain. Specifically, we are focusing on the detection and quantification of glutamate, glutamine and GABA levels. New methods are being developed to reliably measure these compounds and evaluate their applications in neuropharmacological studies.
- To investigate underlying neuronal mechanisms of fMRI signal using preclinical models. Electrophysiological and fMRI signals from the brain are integrated to reveal the neuronal origins of the ongoing fMRI signal.