Welcome to NIDA’s Trangenic Rat Project! The NIDA intramural research program (IRP) with support from IRPs at NIMH, NIAAA, and NINDS have been working over the past few years to generate and characterize the transgenic rats listed below. Many of the lines are still in characterization but others are nearly ready for publication and distribution. The goal of the Transgenic Rat project is to create and characterize a panel of rats for use in models of neurological diseases such as addiction and neurodegeneration. As part of the production and sharing of novel transgenic rats, this website will serve as a data repository for users of the transgenic rats.
All users of NIDA OTTC-generated transgenic rats will agree to provide annual feedback (positive and negative) to be placed on the website for existing and potential users to view. The overall goal is to improve the reproducibility of research using transgenic models of disease.
Most of our strains are distributed by the Rat Resource and Research Center (RRRC), with the exception of TgR–LE Tg(OTTC1005) CX3CR1-Cre-ERT2.
If you are interested in the any of the rats listed below, please request the strain(s) by following the appropriate link in the Request column below.
Promoter: Drd2 (Dopamine receptor D2) PVALb (parvalbumin)
Notes: BAC transgenic using rat parvalbumin promoter to express Cre recombinase in parvalbumin expressing neurons