Da-Ting Lin, Ph.D. - Principal Investigators - The Intramural Research Program of the National Institute on Drug Abuse

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Dr. Lin



Voice: 443-740-2868


Da-Ting Lin, Ph.D., Investigator

Chief, Neural Engineering Unit on-site page link

Post-doctoral Training - 2003-2010, Department of Neuroscience, Johns Hopkins University School of Medicine / HHMI; Advisor: Richard L. Huganir

Ph.D. - 2002, Cellular and Structural Biology, University of Texas Health Science Center at San Antonio. San Antonio, TX

B.S. - 1996, Biology, University of Science and Technology of China, Hefei, China


The research focus in the laboratory is to develop and apply in vivo optical imaging methods as well as computational method for data analysis, to disseminate neuronal circuit dysfunction leading to the development of long term drug addiction and relapse. Currently, the primary focus of the group is to develop the miniScope imaging system allowing simultaneous recording of activity of hundreds of neurons in deep brain regions of freely moving animals. In the long term, in vivo deep brain imaging and closed-loop feedback control of neuronal circuit activity, as well as closed-loop patterned optical of neuronal activity will be explored.

Selected Publications:

  1. Lin DT, Huganir RL. 2007. PICK1 and phosphorylation of the glutamate receptor 2 (GluR2) AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization. J Neurosci 27(50):13903-13908.

  2. Lin DT, Wu J, Holstein D, Upadhyay G, Rourk W, Muller E, Lechleiter JD. 2007. Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes. Neurobiol Aging 28(1):99-111.

  3. Lin DT, Makino Y, Sharma K, Hayashi T, Neve R, Takamiya K, Huganir RL. 2009. Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation. Nat Neurosci 12(7):879-887. PMCID: PMC2712131

  4. Li Y#, Roy BD, Wang W, Zhang L, Zhang LF, Sampson SB, Yang YP, Lin DT#. 2012. Identification of Two Functionally Distinct Endosomal Recycling Pathways for Dopamine D2 Receptor. J. Neurosci 32(21): 7178-7190. # Corresponding Authors

  5. Dickson PE, Ndukum J, Wilcox T, Clark J, Roy BD, Zhang LF, Li Y, Lin DT#, Chesler EJ#. 2014. Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice. Psychopharmacology: Volume 232, Issue 6 (2015), Page 1011-1024, DOI 10.1007/s00213-014-3737-5. # Corresponding Authors

  6. Zhang Y, Cudmore RH1, Lin DT, Linden DJ, Huganir RL. 2015. Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo. Nature Neuroscience 18, 402–407. doi:10.1038/nn.39366

  7. Lee ST, Williams PA, Braine CE, Lin DT, John SWM, Irazoqui PP. 2015. A miniature, fiber-coupled, wireless, deep-brain optogenetic stimulator. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING. vol.PP, no.99, pp.1,1. doi: 10.1109/TNSRE.2015.2391282

  8. Zhang W*, Zhang LF*, Liang B, Schroeder D, Zhang ZW, Cox GA, Li Y#, Lin DT#. 2016. Hyperactive Somatostatin Interneurons Contribute to Excitotoxicity in Neurodegenerative Disorders. Nature Neuroscience doi:10.1038/nn.4257 * equal contribution to the work. # Corresponding Authors

  9. Zhang W, Daly KM, Liang B, Zhang LF, Li, X, Li Y#, Lin DT#. 2016. BDNF Rescues Prefrontal Dysfunction Elicited By Pyramidal Neuron Specific DTNBP1 Deletion In Vivo. J Mol Cell Biol. doi: 10.1093/jmcb/mjw029 # Corresponding Authors

  10. Barbera G*, Liang B*, Zhang LF*, Gerfen CR, Culurciello E, Chen R#, Li Y#, Lin DT#. 2016. Spatially Compact Neural Clusters In The Dorsal Striatum Encode Locomotion Relevant Information. Neuron (In press) doi: 10.1016/j.neuron.2016.08.037 # Corresponding Authors

View more publications at PubMed.

About Dr. Aponte's...

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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