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Featured Research Papers

Jordi Bonaventura

Daniele Caprioli

Featured paper of the Month!

April's Featured Paper!

Role of Dorsomedial Striatum Neuronal Ensembles in
Incubation of Methamphetamine Craving after Voluntary
Abstinence

J Neurosci. 2017 Jan 25;37(4):1014-1027. doi: 10.1523/JNEUROSCI.3091-16.2017.

Daniele Caprioli, Marco Venniro, Michelle Zhang, Jennifer M. Bossert, Brandon L. Warren, Bruce T. Hope, and Yavin Shaham

We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation. We trained rats to selfadminister palatable food pellets (6 d, 6 h/d) and methamphetamine (12 d, 6 h/d). We then assessed relapse to methamphetamine...

You can read more about this paper on PubMed.

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A figure from this month's paper.

Melissa J Sharpe

Hot off the Press paper!

Dopamine transients are sufficient and necessary for
acquisition of model-based associations

Nat Neurosci. 2017 Apr 3. doi: 10.1038/nn.4538. [Epub ahead of print]

Melissa J Sharpe, Chun Yun Chang, Melissa A Liu, Hannah M Batchelor, Lauren E Mueller, Joshua L Jones, Yael Niv & Geoffrey Schoenbaum

Associative learning is driven by prediction errors. Dopamine transients correlate with these errors, which current interpretations limit to endowing cues with a scalar quantity reflecting the value of future rewards. We tested whether dopamine might act more broadly to support learning of an associative model of the environment. Using sensory preconditioning, we show that prediction errors underlying stimulus-stimulus learning can be blocked behaviorally and reinstated by optogenetically activating dopamine neurons. We further show that suppressing the firing of these neurons across the transition prevents normal stimulus-stimulus learning. These results establish that the acquisition of model-based information about transitions between nonrewarding events is also driven by prediction errors and that, contrary to existing canon, dopamine transients are both sufficient and necessary to support this type of learning. Our findings open new possibilities for how these biological signals might support associative learning in the mammalian brain in these and other contexts.

You can read more about this paper on PubMed.

Hot off the Press Archives

Tsung-Ping Su

Dr. Tsung-Ping Su

Reviews to Read

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

Trends Pharmacol Sci. 2016 Apr;37(4):262-78.

Su TP, Su TC, Nakamura Y, Tsai SY.

The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM), an interface between ER and mitochondria. In addition to being able to translocate to the plasma membrane (PM) to interact with ion channels and other receptors, Sig-1R also occurs at the nuclear envelope, where it recruits chromatin-remodeling factors to affect the transcription of genes....

You can read more about this paper on PubMed.

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Related Information...

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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