
Jennifer Bossert and Hannah Kora
Hot Off the Press – November 17 , 2020
Bossert et al. used a rat model of opioid agonist maintenance therapy to study the effect of the novel G-protein-biased mu opioid receptor (MOR) agonist TRV130 on relapse oxycodone seeking and taking during abstinence. They showed that TRV130 decreased oxycodone seeking and taking during abstinence in a partly sex-specific manner and prevented acute oxycodone-induced brain hypoxia. The authors proposed that G-protein-biased MOR agonists, currently in development as analgesics, should be considered as a relapse prevention maintenance treatment for opioid addiction. A translational clinical study at the IRP based on the results from the rat study of Bossert et al. is currently ongoing.
Publication Information
Biological Psychiatry, 88 (12), pp. 935–944, 2020, ISBN: 0006-3223. |