Enhancer viruses for combinatorial cell-subclass-specific labeling. Neuron.
Two studies published last year harnessed single-cell chromatin accessibility to define and test cell-type-distinguishing enhancers for generating AAVs to express transgenes in discrete cell populations, and to study expression correspondence between species. These approaches provide researchers with one avenue to access specific cell types in the brain for targeted population studies and gene therapies. [Read More]