Featured Paper of the Month – February 2018. Learned associations between environmental stimuli and rewards drive learning and motivated behavior. These memories are thought to be encoded by alterations within specific patterns of sparsely distributed neurons called neuronal ensembles that are selectively activated by reward-predictive stimuli. Here we use the Fos promoter to identify strongly… [Read More]
Featured Paper of the Month
High fat diet disrupts endoplasmic reticulum calcium homeostasis in the rat liver.
Featured Paper of the Month – January 2018. From the NIDA IRP Molecular Mechanisms of Cellular Stress and Inflammation Section The endoplasmic reticulum (ER) is cellular organelle that performs critical functions such as the production and processing of proteins, lipids and drugs. The ER also serves as the primary storage site for calcium inside the cell. … [Read More]
Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.
Featured Paper of the Month – December 2017. The etiology and pathophysiology of drug addiction are still not well understood. In this research paper, we show that genetic deletion of mGluR2, a presynaptic glutamate autoreceptor, decreases sensitivity to cocaine reward that causes a compensatory increase in cocaine intake and a decrease in relapse to cocaine-seeking… [Read More]
A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.
Featured Paper of the Month – November 2017
This paper describes three separate studies, conducted with non-human primates, rats, and humans, that investigated the potential contribution of the hormone aldosterone and its mineralocorticoid receptor to alcohol use disorder.
Compulsive Addiction-like Aggressive Behavior in Mice.
Featured Paper of the Month – October 2017
Golden, Sam A; Heins, Conor; Venniro, Marco; Caprioli, Daniele; Zhang, Michelle; Epstein, David H; Shaham, Yavin
Biol Psychiatry, 82 (4), pp. 239–248, 2017, ISSN: 1873-2402 (Electronic); 0006-3223 (Linking)
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Salience and default mode network dysregulation in chronic cocaine users predict treatment outcome.
Featured Paper of the Month – September 2017
Geng, Xiujuan; Hu, Yuzheng; Gu, Hong; Salmeron, Betty Jo; Adinoff, Bryon; Stein, Elliot A; Yang, Yihong
Brain, 140 (5), pp. 1513–1524, 2017, ISSN: 1460-2156 (Electronic); 0006-8950 (Linking).
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The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.
Featured Paper of the Month – August 2017
Zhang, Hai-Ying; Bi, Guo-Hua; Yang, Hong-Ju; He, Yi; Xue, Gilbert; Cao, Jiajing; Tanda, Gianluigi; Gardner, Eliot L; Newman, Amy Hauck; Xi, Zheng-Xiong
Neuropsychopharmacology, 42 (9), pp. 1871–1883, 2017, ISSN: 1740-634X (Electronic); 0893-133X (Linking).
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Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).
Featured Paper of the Month – July 2017
Kumar, Vivek; Moritz, Amy E; Keck, Thomas M; Bonifazi, Alessandro; Ellenberger, Michael P; Sibley, Christopher D; Free, Benjamin R; Shi, Lei; Lane, Robert J; Sibley, David R; Newman, Amy Hauck
J Med Chem, 60 (4), pp. 1478–1494, 2017, ISSN: 1520-4804 (Electronic); 0022-2623 (Linking).
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Lateral Habenula Involvement in Impulsive Cocaine Seeking
Featured Paper of the Month – June 2017
Zapata, Agustin; Hwang, Eun-Kyung; Lupica, Carl R
Neuropsychopharmacology, 42 (5), pp. 1103–1112, 2016, ISSN: 1740-634X (Electronic); 0893-133X (Linking).
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Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.
Featured Paper of the Month – May 2017
Estefania Moreno, Cesar Quiroz, William Rea, Ning-Sheng Cai, Josefa Mallol, Antoni Cortes, Carme Lluis, Enric I Canela, Vicent Casado, Sergi Ferré
J Neurosci, 37 (5), pp. 1176–1186, 2017, ISSN: 1529-2401 (Electronic); 0270-6474 (Linking).
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