Roy A. Wise, Ph.D., F.R.S.C., Senior Investigator - Principal Investigators - The Intramural Research Program of the National Institute on Drug Abuse

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251 Bayview Blvd
Suite 200, Room 08A721A
Baltimore, MD 21224


Phone: 443.740.2460

Roy A. Wise, Ph.D., F.R.S.C., Senior Investigator

Chief, Behavioral Neuroscience Section

Ph.D. - McGill University (thesis advisor: Dalbir Bindra)

B.A., M.A., - California State University


My interest is in the brain mechanisms of motivation and addiction. Our current studies focus on the mesolimbic and nigrostriatal dopamine systems, systems that appear to stamp in or "reinforce" stimulus-stimulus, stimulus-response, and response-outcome learning involved in habit formation. These systems are activated by addictive drugs, unexpected rewards, and reward predictors, and they are modified by experience with drugs of abuse. We are interested in the neuronal inputs that carry reward-predictive signals and we are interested in drug-induced modifications that, for example, change the sensitivity of the system to stress. Our current studies are based on microdialysis studies of intravenous drug self-administration and involve interdisciplinary collaborations involving histochemistry, electrophysiology, in vivo voltammetry, and cell biology. Of particular interest are manipulations of the glutamatergic, cholinergic, and CRF inputs to the ventral tegmental area using receptor-specific neurotoxins, small interfering RNA, and viral overexpression of the glutamate-1 transporter.

Selected Publications:

View more publications at PubMed.

More about Dr. Wise

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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