Elliot A. Stein, Ph.D., Senior Investigator - Principal Investigators - The Intramural Research Program of the National Institute on Drug Abuse

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PRINCIPAL INVESTIGATORS

photo of Dr. Stein

CONTACT ME

NIDA-IRP
251 Bayview Blvd
Suite 200, Room 07A711A
Baltimore, MD 21224

Phone: 443-740-2650
Fax: 443-740-2753

estein@mail.nih.gov

Elliot A. Stein, Ph.D., Senior Investigator

Chief, Neuroimaging Research Branch

Post-doctoral training - Behavioral Neurobiology, California Institute of Technology (advisor Dr. James Olds)

Ph. D. - Neurophysiology, University of Maryland, School of Medicine

B.A. - Biology, Quinnipiac University

RESEARCH INTERESTS

Our research is directed at understanding the neurobiological mechanisms underlying human drug use and addiction. Using a number of MRI based (e.g. fMRI, MR spectroscopy, functional connectivity, DTI) and PET (dopamine, serotonin systems) imaging techniques in both human and animal models, we aim to understand how both acute and chronic drug administration alters neuronal and cognitive processing and subsequent behavioral outcome. Our human imaging research, centered mostly on cocaine and nicotine dependence, emphasizes the importance of cognitive, affective, personality and environmental interactions with the drug’s pharmacological properties. More recent studies are examining these properties in marijuana, ecstasy and methamphetamine users. Drug using individuals and healthy matched control subjects are employed to test specific hypotheses related to such cognitive constructs as attention, reward processing, craving, affect, decision making and response inhibition. The consequences of chronic drug use on systems level neuroplasticity are examined longitudinally during drug withdrawal and treatment regimens. Together with our collaborators, we have begun to examine how specific individual genetic polymorphisms help explain the group variance imaging endophenotypes to better understand trait related predisposition and hopefully, treatment outcome. Finally, rodent and non-human primate imaging models are employed to address the biophysical bases of the fMRI signal and, using chronic drug use models unavailable in human research, better understand where and how various neuropharmacological manipulations alter local and circuit level neuronal functions. The long-term goal of this research is to develop more efficacious strategies to both treat existing and help prevent future drug use in high risk populations.

Selected Publications:

View more publications at PubMed.

More about Dr. Stein

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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