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Transgenic Rats

Welcome to NIDA’s Trangenic Rat Project! The NIDA intramural research program (IRP) with support from IRPs at NIMH, NIAAA, and NINDS have been working over the past few years to generate and characterize the transgenic rats listed below. Many of the lines are still in characterization but others are nearly ready for publication and distribution. The goal of the Transgenic Rat project is to create and characterize a panel of rats for use in models of neurological diseases such as addiction and neurodegeneration. As part of the production and sharing of novel transgenic rats, this website will serve as a data repository for users of the transgenic rats.

All users of NIDA OTTC-generated transgenic rats will agree to provide annual feedback (positive and negative) to be placed on the website for existing and potential users to view. The overall goal is to improve the reproducibility of research using transgenic models of disease. If you are interested in the any of the rats listed below, please either use the link(s) below for instructions on how to request the strain(s) from RRRC or click the following link to our Transgenic Rat Request page.

LE = Long Evans, SD = Sprague-Dawley

OTTC Strain Name

Request

Promoter

Transgene

Notes

LE-Tg(cFos-eGFP)2Ottc RRRC#766 cFos  eGFP Reporter rat expressing eGFP in cFos expressing cells
LE-Tg(cFos-LacZ)1Ottc RRRC#759 cFos  LacZ Reporter rat expressing beta-galactosidase in cFos expressing cells
LE-Tg(cFos-TetO-iCre)4Ottc Transgenic Rat Request Form cFos  iCre Cre recombinase expressed from cFos promoter and controllable by Tet activator/repressor
LE-Tg(DAT-iCre)6Ottc RRRC#758 DAT (dopamine transporter) iCre BAC transgenic using rat DAT promoter to express Cre recombinase in dopaminergic neurons
LE-Tg(DIO-iRFP)3Ottc RRRC#747 EF1alpha iRFP Cre recombinase reporter rat on Long Evans (LE) background expressing iRFP
SD-Tg(DIO-iRFP)9Ottc RRRC#748 EF1alpha iRFP Cre recombinase reporter rat on Long Evans (LE) background expressing iRFP
LE-Tg(DIO-mCherry)2Ottc RRRC#687 EF1alpha mCherry Cre recombinase reporter rat expressing mCherry
LE-Tg(EF1a-TetR)1Ottc RRRC#761 EF1alpha TetR Expresses TetR using "ubiquitous" promoter; to be used in combination with TetO containing rats or viral vectors 
LE-Tg(GAD1-iCre)3Ottc RRRC#751 GAD1 (glutamate decarboxylase 1) iCre BAC transgenic using rat GAD1 promoter to express Cre recombinase in GABAergic neurons
LE-Tg(GlyT2-iCre)1Ottc Transgenic Rat Request Form GlyT2 (glycine transporter) iCre BAC transgenic using rat GlyT2 promoter to express Cre recombinase in glycinergic neurons
LE-Tg(Drd1a-iCre)3Ottc RRRC#767 Drd1 (Dopamine receptor D1)  iCre BAC transgenic using rat dopamine receptor 1 promoter to express Cre recombinase in D1R neurons
LE-Tg(Drd2-iCre)1Ottc RRRC#768 Drd2 (Dopamine receptor D2)  iCre BAC transgenic using rat dopamine receptor 2 promoter to express Cre recombinase in D2R neurons
LE-Tg(Pvalb-iCre)2Ottc RRRC#773 PVALb (parvalbumin) iCre BAC transgenic using rat parvalbumin promoter to express Cre recombinase in parvalbumin expressing neurons
LE-Tg(vGlut2-iCre)3Ottc Transgenic Rat Request Form vGLUT2  (vesicular glutamate transporter 2) iCre BAC transgenic using rat vGLUT2 promoter to express Cre recombinase in glutamatergic neurons
TgR - LE Tg(OTTC1004) GFAP-Cre-ERT2 Transgenic Rat Request Form GFAP (glia fibrillary associated protein) Cre-ERT2 BAC transgenic using rat GFAP promoter to express Cre recombinase in astrocytes
TgR - LE Tg(OTTC1005) CX3CR1-Cre-ERT2 Transgenic Rat Request Form CX3CR1 (chemokine receptor CX3CR1) Cre-ERT2 BAC transgenic using rat CX3CR1 promoter to express Cre recombinase in microglia