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Hong Gu, Ph.D.

Research Associate |

Dr. Gu received her B.S. (1993) and M.S. (1996) in Electronic Engineering at Hefei University of Technology and University of Science and Technology of China, respectively. She received her Ph.D. in Biomedical Engineering from Shanghai Jiao Tong University, China in 2000. She then went on to postdoctoral associate position from 2000 to 2003 in the Functional Neuroimaging Laboratory at Weill Medical College of Cornell University in New York City. In 2003, she joined the Neuroimaging Research Branch at the National Institute on Drug Abuse (NIDA) as a research associate. Her research interests focus on the development and application of functional magnetic resonance imaging (fMRI) and functional connectivity MRI methodologies.


  • Development of reesting-state functional connectivity analysis methods
  • Development of simultaneous VASO, perfusion, and BOLD imaging techniques
  • Development of efficient fMRI imaging techniques to reduce susceptibility artifacts
  • Application of novel data analysis methods to fMRI data


  • Shin W, Gu H, & Yang Y. Incidental magnetization transfer contrast by fat saturation preparation pulses in multislice Look-Locker echo planar imaging. Magn. Reson. Med. 2009, 62:520-526.
  • Geng X, Christensen G, Gu H, Ross TJ, & Yang Y. Implicit reference-based group-wise image registration and its application to structural and functional MRI. NeuroImage 2009, 47:1341-1351.
  • Hong EL, Gu H, Yang Y, Ross TJ, Salmeron BJ, Buchholz B, Thaker GK, & Stein EA. Association of nicotine addiction and nicotine’s actions with separate cingulated cortex functional circuits. Arch Gen Psychiatry 2009, 66:431-441.
  • Wu CW, Gu H, Lu H, Stein EA, Chen JH, & Yang Y. Mapping functional connectivity based on synchronized CMRO2 fluctuations during the resting state. NeuroImage 2009, 45:694-701.
  • Shin W, Gu H, & Yang Y. Fast high-resolution T1 mapping using inversion-recovery Look-Locker echo-planar imaging at steady state: optimization for accuracy and reliability. Magn. Reson. Med. 2009, 61:899-906.
  • Wu CW, Gu H, Lu H, Stein EA, Chen JH, & Yang Y. Frequency specificity of functional connectivity in brain networks. NeuroImage 2008, 42:1047-1055.
  • Lu H, Zuo Y, Gu H, Waltz JA, Zhan W, Scholl CA, Rea W, Yang Y, & Stein EA. Synchronized delta oscillations correlate with the resting-state fMRI signal. Proc Natl Acad Sci 2007, 104:18265–18269.
  • Gu H, Lu H, Ye FQ, Stein EA, & Yang Y. Noninvasive quantification of cerebral blood volume in humans during functional activation. NeuroImage, NeuroImage 2006, 30:377–387.
  • Gu H, Stein EA, & Yang Y. Nonlinear response of cerebral blood volume, blood flow and blood oxygenation signals during visual stimulation. Magn Reson Imag 2005, 23:921–928.
  • Yang Y, Gu H, Silbersweig DA, & Stern E. Simultaneous perfusion and BOLD measurements using Single-Shot Interleaved Z-Shim EPI (SSIZS-EPI). Magn Reson Imag 2005, 53:1207–1211.
  • Yang Y, Gu H, & Stein EA. Simultaneous MRI acquisition of blood volume, blood flow, and blood oxygenation information during brain activation. Magn Reson Imag 2004, 52:1407–1417.
  • Feng H, Gu H, Silbersweig DA, Stern E, & Yang Y. Single-shot MR imaging using trapezoidal-gradient based Lissajous trajectories. IEEE Trans Med Imag 2003, 22:925–932.
  • Zhan W, Gu H, Xu S, Silbersweig DA, Stern E, & Yang Y. Circular spectrum mapping for intravoxel fiber structures based on high angular resolution apparent diffusion coefficients. Magn Reson Imag 2003, 49:1077–1088.
  • Gu H, Feng H, Zhan W, Xu S, Silbersweig DA, Stern E, & Yang Y. Single-Shot Interleaved Z-Shim EPI with optimized compensation for signal losses due to susceptibility-induced field inhomogeneity at 3T. NeuroImage 2002, 17:1358–1364.
  • Yang Y, Gu H, Zhan W, Xu S, Silbersweig DA, & Stern E. Simultaneous perfusion and BOLD imaging using reversed spiral scanning at 3T: characterization of functional contrast and susceptibility artifacts. Magn Reson Med 2002, 48:278–289.
  • Zhan W, Gu H, Silbersweig DA, Stern E, & Yang Y. Inversion profiles of adiabatic inversion pulses for flowing spins: the effects on labeling efficiency and labeling accuracy in perfusion imaging with pulsed arterial spin-labeling. Magn Reson Imag 2002, 20:487–494.
  • Gu H, Engelien W, Feng H, Silbersweig DA, Stern E, & Yang Y. Mapping transit, randomly occurring neuropsychological events using independent component analysis. NeuroImage 2001, 14:1432–1443.
  • Yang Y, Engelien W, Xu S, Gu H, Stern E, & Silbersweig DA. Transit time, trailing time, and cerebral blood flow during brain activation: measurement using multislice, pulsed spin-labeling perfusion imaging. Magn Reson Med 2000, 44:680–685.
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