Barry J. Hoffer, M.D., Ph.D. - Scientist Emeritus - The Intramural Research Program of the National Institute on Drug Abuse

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Biomedical Research Center
251 Bayview Blvd., Room 04A521
Baltimore, Maryland 21224

Phone: (443) 740-2463

Fax: (443) 740-2855


Barry J. Hoffer, M.D., Ph. D, Scientist Emeritus

Ph.D. - Physiology, University of Rochester School of Medicine

M.D. - University of Rochester School of Medicine


Our section studies animal models of neurodegenerative disorders. We focus on both pathophysiology and novel therapeutic interventions. Our animal models focus on Parkinson's Disease, stroke, aging and traumatic brain injury. Unique models include: transgenic mouse models of Parkinson's Disease - the MitoPark mouse, trophic factors as novel therapeutic agents - GDNF, BMPs, CDNF, MANF, and mitochondrial mechanisms in aging - the mtDNA mutator mouse.

Selected Publications:

  1. Tumor necrosis factor-α synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice. Baratz R, Tweedie D, Rubovitch V, Luo W, Yoon JS, Hoffer BJ, Greig NH, Pick CG. J Neurochem. 2011 Jul 8. doi: 10:1111/j.1471-4159.2011. [Epub ahead of print]

  2. Enhanced survival of dopaminergic neuronal transplants in hemi-Parkinsonian rats by the p53 inactivator PFT-α Chou J, Greig NH, Reiner D, Hoffer BJ, Wang Y. Cell Transplant. 2011 Feb 3. [Epub ahead of print]

  3. Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease. Good CH, Hoffman AF, Hoffer BJ, Chefer VI, Shippenberg TS, Bäckman CM, Larsson NG, Olson L, Gellhaar S, Galter D, Lupica CR. FASEB J. 2011 Apr;25(4):1333-44. Epub 2011 Jan 13.

  4. High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio. Ross JM, Öberg J, Brené S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20087-92. Epub 2010 Nov 1.

  5. Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury. Airavaara M, Chiocco MJ, Howard DB, Zuchowski KL, Peränen J, Liu C, Fang S, Hoffer BJ, Wang Y, Harvey BK. Exp Neurol. 2010 Sep;225(1):104-13. Epub 2010 Jun 2.

About Dr. Hoffer's...

IRP Training Opportunities...

2009 Postbacs
Postdoc, Predoc, Postbac and Summer Student training opportunities available!

2009 Summer Students
Research & Training Program for Under-represented Populations

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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