Antonello Bonci, M.D. Scientific Director - Principal Investigators - The Intramural Research Program of the National Institute on Drug Abuse

Skip Navigation

PRINCIPAL INVESTIGATORS

poto of Dr. Bonci

CONTACT ME

NIDA-IRP
251 Bayview Boulevard,
Rm 04A521
Baltimore, MD 21224

Phone: (443) 740-2463

boncia@mail.nih.gov

Antonello Bonci, M.D., Scientific Director

Chief, Synaptic Plasticity Section on-site page link

Post-doctoral Residence - Department of Neurology - University of California, San Francisco

M.D. - Sacred Heart School of Medicine - Rome, Italy

RESEARCH INTERESTS

Chronic exposure to drugs of abuse causes several cellular and behavioral adaptations such as tolerance, dependence, and sensitization. The main goal of my laboratory is to understand the synaptic properties of neurons in brain areas relevant to drug addiction such as the ventral  tegmental area (VTA), the nucleus accumbens (NAcc), and the prefrontal cortex (PFC). My laboratory was the first to demonstrate that drugs of abuse such as cocaine produce a form of synaptic plasticity called long-term potentiation (LTP). The aim of my research is to apply electrophysiological, optogenetic, molecular, and behavioral approaches to elucidate the long-term effects that are produced by chronic administration of drugs of abuse such as cocaine and alcohol. Understanding the basic mechanisms at the synaptic level that underlie the long-term effects of these drugs will likely open new avenues for therapeutic strategies against the many symptoms of substance use disorders.

Selected Publications:

View more publications at PubMed.

More about Dr. Bonci

Health and Human Services Logo National Institute on Drug Abuse Logo


The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

PDF documents require the free Adobe Reader. Microsoft Word documents require the free Microsoft Word viewer. Microsoft PowerPoint documents require the free Microsoft PowerPoint viewer. Flash content requires the free Adobe Flash Player.