Hot Off the Press! – April 2015
Wang, Dong V; Yau, Hau-Jie; Broker, Carl J; Tsou, Jen-Hui; Bonci, Antonello; Ikemoto, Satoshi
Nat Neurosci, 18 (5), pp. 728–735, 2015, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
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Archives for 2015
An in vitro model of human neocortical development using pluripotent stem cells: cocaine-induced cytoarchitectural alterations
Featured Paper of the Month – April 2015
Published in Disease Models & Mechanisms by Kindberg, Abigail A; Bendriem, Raphael M; Spivak, Charles E; Chen, Jia; Handreck, Annelie; Lupica, Carl R; Liu, Jinny; Freed, William J; Lee, Chun-Ting
Neocortical development involves ordered specification of forebrain cortical progenitors to various neuronal subtypes, ultimately forming the layered cortical structure. Modeling of this process using human pluripotent stem cells (hPSCs) would enable mechanistic studies of human neocortical development, while providing new avenues for exploration of developmental neocortical abnormalities…
Clonidine Maintenance Prolongs Opioid Abstinence and Decouples Stress From Craving in Daily Life: A Randomized Controlled Trial With Ecological Momentary Assessment
Hot Off the Press! – March 2015
Kowalczyk, William J; Phillips, Karran A; Jobes, Michelle L; Kennedy, Ashley P; Ghitza, Udi E; Agage, Daniel A; Schmittner, John P; Epstein, David H; Preston, Kenzie L
Am J Psychiatry, 172 (8), pp. 760–767, 2015, ISSN: 1535-7228 (Electronic); 0002-953X (Linking).
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Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer.
Featured Paper of the Month – March 2015
Published in Molecular Pharmacology by Guitart, Xavier; Navarro, Gemma; Moreno, Estefania; Yano, Hideaki; Cai, Ning-Sheng; Sanchez-Soto, Marta; Kumar-Barodia, Sandeep; Naidu, Yamini T; Mallol, Josefa; Cortes, Antoni; Lluis, Carme; Canela, Enric I; Casado, Vicent; McCormick, Peter J; Ferre, Sergi
The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous studies suggested that this heteromer could be involved in the ability of D3R agonists to potentiate locomotor activation induced by D1R agonists. It has also been postulated that its overexpression plays a role in L-dopa-induced dyskinesia and in drug addiction. However, little is known about its biochemical properties…
Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons
Hot Off the Press! – February 2015
Zhang, Shiliang; Qi, Jia; Li, Xueping; Wang, Hui-Ling; Britt, Jonathan P; Hoffman, Alexander F; Bonci, Antonello; Lupica, Carl R; Morales, Marisela
Nat Neurosci, 18 (3), pp. 386–392, 2015, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
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Synthesis and immunological effects of heroin vaccines
Featured Paper of the Month – February 2015
Published in Organic Biomolecular Chemistry by Li, Fuying; Cheng, Kejun; Antoline, Joshua F G; Iyer, Malliga R; Matyas, Gary R; Torres, Oscar B; Jalah, Rashmi; Beck, Zoltan; Alving, Carl R; Parrish, Damon A; Deschamps, Jeffrey R; Jacobson, Arthur E; Rice, Kenner C
Three haptens have been synthesized with linkers for attachment to carrier macromolecules at either the piperidino-nitrogen or via an introduced 3-amino group. Two of the haptens, with a 2-oxopropyl functionality at either C6, or at both the C3 and C6 positions on the 4,5-epoxymorphinan framework, as well as the third hapten (DiAmHap) with diamido moieties at both the C3 and C6 positions, should be much more stable in solution, or in vivo in a vaccine, than a hapten with an ester in one of those positions, as found in many heroin-based haptens…
SERCaMP: a carboxy-terminal protein modification that enables monitoring of ER calcium homeostasis
Featured Paper of the Month – January 2015
Published in Molecular Biology of the Cell by Henderson, Mark J; Wires, Emily S; Trychta, Kathleen A; Richie, Christopher T; Harvey, Brandon K
Endoplasmic reticulum (ER) calcium homeostasis is disrupted in diverse pathologies, including neurodegeneration, cardiovascular diseases, and diabetes. Temporally defining calcium dysregulation during disease progression, however, has been challenging…