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Featured Research Papers

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A figure from this month's paper.

Featured Paper Archives
Featured paper of the Month!

March's Featured Paper!

Large-Scale Brain Networks in the Awake, Truly Resting Marmoset Monkey

The Journal of Neuroscience, 16 October 2013, 33(42): 16796-16804

Annabelle M. Belcher, Cecil C. Yen, Haley Stepp, Hong Gu, Hanbing Lu, Yihong Yang, Afonso C. Silva, and Elliot A. Stein

Resting-state functional MRI is a powerful tool that is increasingly used as a noninvasive method for investigating whole-brain circuitry and holds great potential as a possible diagnostic for disease. Despite this potential, few resting-state studies have used animal models (of which nonhuman primates represent our best opportunity of understanding complex human neuropsychiatric disease), and no work has characterized networks in awake, truly resting animals. Here we present results from a small New World monkey that allows for the characterization of resting-state networks in the awake state. Six adult common marmosets (Callithrix jacchus) were acclimated to light, comfortable restraint using individualized helmets. Following behavioral training, resting BOLD data were acquired during eight consecutive 10 min scans for each conscious subject. Group independent component analysis revealed 12 brain networks that overlap substantially with known anatomically constrained circuits seen in the awake human. Specifically, we found eight sensory and “lowerorder” networks (four visual, two somatomotor, one cerebellar, and one caudate–putamen network), and four “higher-order” association networks (one default mode-like network, one orbitofrontal, one frontopolar, and one network resembling the human salience network). In addition to their functional relevance, these network patterns bear great correspondence to those previously described in awake humans. This first-of-its-kind report in an awake New World nonhuman primate provides a platform for mechanistic neurobiological examination for existing disease models established in the marmoset.

You can read more about this paper at the website for theJournal of Neuroscience.

February's Featured Paper!

Dopamine D4 Receptor Excitation of Lateral Habenula Neurons via Multiple Cellular Mechanisms

The Journal of Neuroscience, October 23, 2013 • 33(43):16853–16864 • 16853

Cameron H. Good, Huikun Wang, Yuan-Hao Chen, Carlos A. Mejias-Aponte, Alexander F. Hoffman, and Carl R. Lupica

You can read more about this paper at the website for theJournal of Neuroscience.

January's Featured Paper!

Resting-State Glutamate and GABA Concentrations Predict Task-Induced Deactivation in the Default Mode Network

J. NEUROSCI 20 November 2013, 33(47): 18566-18573

Yuzheng Hu, Xi Chen, Hong Gu, and Yihong Yang

You can read more about this paper at the website for theJournal of Neuroscience.

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A figure from this month's paper.
A figure from this month's paper.

Hot off the Press Archives
Featured paper of the Month!

Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease

Nature Neuroscience 17, 232–239 (2014)

Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E Homanics, John Peever, Kenner C Rice, Ling-gang Wu, Hui-Lin Pan & Li Zhang

Although postsynaptic glycine receptors (GlyRs) as αβ heteromers attract considerable research attention, little is known about the role of presynaptic GlyRs, likely α homomers, in diseases. Here, we demonstrate that dehydroxylcannabidiol (DH-CBD), a nonpsychoactive cannabinoid, can rescue GlyR functional deficiency and exaggerated acoustic and tactile startle responses in mice bearing point mutations in α1 GlyRs that are responsible for a hereditary startle-hyperekplexia disease....

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Neural Estimates of Imagined Outcomes in the Orbitofrontal Cortex Drive Behavior and Learning

Neuron Volume 80, Issue 2, 507-518, 16 October 2013

Yuji K. Takahashi, Chun Yun Chang, Federica Lucantonio, Richard Z. Haney, Benjamin A. Berg, Hau-Jie Yau, Antonello Bonci, and Geoffrey Schoenbaum

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Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid

Nature Neuroscience published online 13 October 2013; doi:10.1038/nn.3540

Zuzana Justinova, Paola Mascia, Hui-Qiu Wu, Maria E Secci, Godfrey H Redhi, Leigh V Panlilio, Maria Scherma, Chanel Barnes, Alexandra Parashos, Tamara Zara, Walter Fratta, Marcello Solinas, Marco Pistis, Jack Bergman, Brian D Kangas, Sergi Ferré, Gianluigi Tanda, Robert Schwarcz, and Steven R Goldberg

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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