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Branch Overview
Branch Chief: Kenzie L. Preston, Ph.D. 
The Clinical Pharmacology and Therapeutics Research Branch conducts studies in human volunteers in order to understand, treat, and prevent drug abuse and dependence. Principal Investigators direct their own independent research projects though they frequently collaborate both within and beyond the branch. The investigators conduct cutting-edge human laboratory studies and outpatient clinical trials to investigate phenomena such as drug metabolism, the effects of drug deprivation on performance and subjective response, the modulation of the effects of illicit drugs by potential pharmacotherapies, concentrations of therapeutic and illicit drugs in treatment patients, and the precipitants and process of relapse.
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Treatment Section (The Archway Clinic)
Section Chief: Kenzie L. Preston, Ph.D.
- Evaluation of treatments of opioid and cocaine dependence
- Evaluation of treatments of drug dependence in HIV infected patients
- Psychological and methodological issues in substance abuse treatment/research
- Quantifying exposure to illicit drugs & psychosocial stress in real time
- Prevention of relapse in addiction
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Chemistry and Drug Metabolism Section
Section Chief: Marilyn A. Huestis, Ph.D
- Effects of Sativex and oral THC on attention, affect, working memory, reversal learning, physiology, and brain activation
- Neurobiology and pharmacokinetics of acute MDMA administration
- Assessment of a cannabinoid antagonist in human cannabis users
- Developmental effects and monitoring of in utero drug exposure
- Pharmacodynamics and pharmacokinetics of smoked drugs of abuse
- Detection of drugs of abuse in alternative biological fluids and tissues
- Pharmacodynamics and pharmacokinetics of drugs of abuse
- Role of multidrug resistance protein 1a (MDR1a) in methamphetamine and methylenedioxymethamphetamine
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Nicotine Psychopharmacology Section
Section Chief: Stephen Heishman, Ph.D.
- Effect of nicotine or tobacco withdrawal on cognition and brain function
- Effect of nicotine on elements of attention in smokers and nonsmokers
- Cue-reactivity and nicotine reinforcement in smokers with and without schizophrenia
- Cue-reactivity and nicotine reinforcement in adolescent smokers
- Determination of optimal biomarkers to distinguish smokers and nonsmokers
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IRP Training Opportunities...
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