PRINCIPAL INVESTIGATORS

Human Molecular Genetics

• Molecular genetic bases of individual differences in vulnerability to develop dependence on an addictive substance
• Molecular genetic bases of individual differences in ability to quit smoking (and make other health-related behavior changes)
• Molecular genetic bases of individual differences in other related phenotypes

Human Clinical Studies

• Recruitment and characterization of subjects for genome wide association studies
• Assessments of individual differences in drug responses in individuals who have selected genotypes
• Assessments of individual differences in treatment responses in individuals who have selected genotypes

Mouse Genetics

• Gene-gene interactions: effects on responses to psychostimulants
• Effects of knockouts on drug related behaviors
• Effects of mouse models of human allelic variants in tests of drug response
• Effects of mouse models of human allelic variants in altering synaptic connectivity