Yavin Shaham, Ph.D., Senior Investigator - Principal Investigators - The Intramural Research Program of the National Institute on Drug Abuse

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PRINCIPAL INVESTIGATORS

Yavin Shaham, Ph.D., Senior Investigator

CONTACT ME

Dr. Yavin Shaham
Behavioral Neuroscience Branch
NIH/NIDA/IRP
251 Bayview Blvd, Suite 200
Baltimore, MD 21224

Voice: (443) 740-2723

Fax: (443) 740-2827


Yavin Shaham, Ph.D., Senior Investigator

Branch Chief, Behavioral Neuroscience Branch on-site page link
Section Chief, Neurobiology of Relapse Section on-site page link

Ph.D. - 1992, Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland

M.A. - 1988, Psychology, Hebrew University, Jerusalem, Israel

B.S. - 1986, Biology & Psychology, Hebrew University, Jerusalem, Israel



RESEARCH INTERESTS

We use rat models to study the cellular and neuroanatomical mechanisms that underlie relapse to drug and palatable food seeking induced by stressors and drug-associated or food-associated cues (Yavin Shaham group). We also study neurophysiological mechanisms of addictive drugs and motivated behavior (Eugene Kiyatkin group). Our current research projects include:

Current projects of Shaham group:

  • Incubation of drug craving after forced and self-imposed abstinence
  • Relapse to palatable food seeking
  • Context-induced relapse to drug seeking
  • Relapse to alcohol seeking

Current projects of Eugene Kiyatkin group (In-vivo electrophysiology unit):

  • Physiological analysis of motivated behavior using single-unit recording, iontophoresis, EEG/EMG, brain thermorecording, and glutamate electrochemistry
  • Neurophysiological and neurochemical mechanisms of action of drugs of abuse (cocaine, nicotine)
  • Alterations in blood-brain barrier in normal brain functions and during drug intoxication



Selected Publications:

  1. Bossert JM, Stern AL, Theberge F, Koya E, Hope BT, Shaham Y (2011) Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin. Nature Neuroscience 14:420-422

  2. Badiani A, Belin D, Epstein DH, Calu D, Shaham Y (2011) Heroin and cocaine addictions: the differences do matter. Nature Reviews Neuroscience 12:685-700

  3. Bossert JM, Stern AL, Theberge FR, Marchant MJ, Wang HL, Morales M, Shaham Y (2012) Role of projections from ventral medial prefrontal cortex to nucleus accumbens shell in context-induced reinstatement of heroin seeking. The Journal of Neuroscience 32:4982-4991

  4. Marchant NJ, Khuc TN, Pickens CL, Bonci A, Shaham Y (2013) Context-induced relapse to alcohol seeking after punishment in a rat model. Biological Psychiatry 73:256-262

  5. Marchant NJ, Kaganovsky K, Caprioli D, Rabei R, Bossert JM, Bonci A, Shaham Y (2014) Lateral hypothalamus is critical for context-induced reinstatement to alcohol seeking after punishment-imposed abstinence. The Journal of Neuroscience 34:7447-7457

  6. Kiyatkin EA, Kim A, Wakabayashi KT, Baumann MH, Shaham Y (2014) Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use. The Journal of Neuroscience 34:7754 –7762

  7. Li X, Rubio FJ, Zeric T, Bossert JM, Cates H, Kennedy P, Liu QR, Cimbro R, Nestler EJ, Hope BT, Shaham Y (2015) Incubation of methamphetamine craving is associated with selective increases in genes encoding growth factors, glutamate receptors, and epigenetic enzymes in cue-activated Fos-expressing dorsal striatum neurons. The Journal of Neuroscience 35:8232-8344

  8. Caprioli D, Venniro M, Zeric T, Li, X, Adhikary S, Madangopal R, Marchant NJ, Lucantonio F, Schoenbaum G, Bossert JM, Shaham Y (2015) Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model. Biological Psychiatry 78:463-473

  9. Marchant NJ, Campbell EJ, Harvey BK, Kaganovsky K, Adhikary S, Heins R, Whitaker LR, Hope BT, Prisinzano TE, Vardy E, Bonci A, Bossert JM, Shaham Y (2016) Role of ventral subiculum in context-induced relapse to alcohol seeking after punishment-imposed abstinence. The Journal of Neuroscience 36:3281-3294

  10. Heilig M, Epstein DE, Nader M, Shaham Y (2016) It is time to connect: Addiction neuroscience and social context. Nature Review Neuroscience (in press)

About Dr. Shaham's...

IRP Training Opportunities...


2009 Postbacs
Postdoc, Predoc, Postbac and Summer Student training opportunities available!


2009 Summer Students
Research & Training Program for Under-represented Populations

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The National Institute on Drug Abuse (NIDA), is part of the National Institutes of Health (NIH), the principal biomedical and behavioral research agency of the United States Government. NIH is a component of the U.S. Department of Health and Human Services.

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