CONTACT ME |
Dr. Yavin Shaham
Behavioral Neuroscience Branch
NIH/NIDA/IRP
251 Bayview Blvd, Suite 200
Baltimore, MD 21224
Voice: (443) 740-2723
Fax: (443) 740-2827
Yshaham@intra.nida.nih.gov
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Yavin Shaham, Ph.D., Senior Investigator
Branch Chief, Behavioral Neuroscience Branch 
Section Chief, Neurobiology of Relapse Section
Ph.D. - 1992, Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland
M.A. - 1988, Psychology, Hebrew University, Jerusalem, Israel
B.S. - 1986, Biology & Psychology, Hebrew University, Jerusalem, Israel
RESEARCH INTERESTS
We use rat models to study the cellular and neuroanatomical mechanisms that underlie relapse to drug and palatable food seeking induced by stressors and drug-associated or food-associated cues (Yavin Shaham group). We also study neurophysiological mechanisms of addictive drugs and motivated behavior (Eugene Kiyatkin group). Our current research projects include:
Current projects of Shaham group:
- Incubation of drug craving
- Relapse to palatable food seeking during dieting in female and male rats
- Context-induced relapse to drug seeking
- Relapse to alcohol seeking
Current projects of Eugene Kiyatkin group (In-vivo electrophysiology unit):
- Physiological analysis of motivated behavior using single-unit recording, iontophoresis, EEG/EMG, brain thermorecording, and glutamate electrochemistry
- Neurophysiological and neurochemical mechanisms of action of drugs of abuse (cocaine, nicotine)
- Alterations in blood-brain barrier in normal brain functions and during drug intoxication
Selected Publications:
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Lu L, Hope BT, Dempsey J, Liu S, Bossert JM, Shaham Y (2005) Central amygdala ERK signaling pathway is critical to incubation of cocaine craving. Nature Neuroscience 8:212-219
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Ghitza UE, Nair SG, Golden SA, Gray SM, Uejima JL, Bossert JM, Shaham Y (2007) Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse model. The Journal of Neuroscience 27:11522-11532
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Bossert JM, Poles G, Wihbey K, Koya U, Shaham Y (2007) Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. The Journal of Neuroscience 27:12655-12663
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Conrad KL, Tseng K, Uejima J, Reimers J, Heng L, Shaham Y, Marinelli M, Wolf ME (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118-121
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Lu L, Wang X, Wu P, Zhao M, Morales M, Harvey BK, Hoffer BJ, Shaham Y (2009) Role of ventral tegmental area GDNF in incubation of cocaine craving. Biological Psychiatry 66:137-145
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Nair SG, Navarre BM, Cifani C, Pickens CL, Bossert JM, Shaham Y (2011) Role of dorsal medial prefrontal cortex dopamine D1-family receptors in relapse to high-fat food seeking induced by the anxiogenic drug yohimbine. Neuropsychopharmacology 36:497-510
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Bossert JM, Stern AL, Theberge F, Koya E, Hope BT, Shaham Y (2011) Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin. Nature Neuroscience 14:420-422
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Pickens CL, Airavaara M, Theberge F, Fanous S, Hope BT, Shaham Y (2011) Neurobiology of incubation of drug craving. Trends in Neuroscience (in press)
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Kiyatkin EA, Smirnov, M.S. (2010) Rapid EEG desynchronization and EMG activation induced by intravenous cocaine in freely moving rats: a peripheral, nondopamine neural triggering. American Journal of Physiology 298:R285-R300
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Lenoir M, Kiyatkin EA (2011) Critical role of peripheral actions of nicotine in mediating its central effects. Neuropsychopharmacology(in press)
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